Apoptosis
| PAG Title | Apoptosis |
| PAG ID | WIG001837 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | Apoptosis is a genetically controlled program by which the cell commits suicide in response to external or intenal stimuli, thereby eliminating excess, damaged and otherwise unwanted cells. It is mediated by the caspase family of proteases, which cleaves multiple cellular substrates, leading to the morphologic changes that characterize the apoptotic cell. These include fragmentation of the cytoplasm and nucleus, chromatin condensation and fragmentation, cytoskeletal collapse, membrane blebbing, and finally, disintegration of the cell into apoptotic bodies, which are engulfed by adjacent cells. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,929 |
| Information Content | Rich |
| Other IDs | SPIKE00011 |
| Base PAG ID | WIG001837 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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